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In contrast, studies have demonstrated that the inhibition of glutamine metabolism in cancer cells using the DON precursor drug DRP-104 results in an augmentation of the number of NK and NK T-cells within the immune microenvironment, thereby enhancing anti-tumor immunity [121]

Watermann I, Schmitt B, Stellmacher F, Mller J, Gaber R, Kugler C, et al

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Robinson M

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One meta-analysis found that glutamate is reduced and glutamine is increased in the ACC in patients with schizophrenia, and both decrease more markedly with age in patients [38]