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These effects have made Omav a potential candidate for FRDA therapy, since the downregulation and reduced expression of NRF2, coupled with defective mitochondrial bioenergetics have been widely reported in FRDA patients
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Astrocyte energy and neurotransmitter metabolism in Alzheimers disease: Integration of the glutamate/GABA-glutamine cycle
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New England Journal of Medicine , 368: 1575-1584 Zhu W, et al
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