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Description
Not only can you experience nausea, but also vomiting with severe cases of constipation

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COMT is involved in converting 2-hydroxyestradiol (an antiestrogen) to 2-methoxyestradiol (proestrogen), creating a hyper-estrogenic milieu due to the decrease in antiestrogen and an increase in proestrogen
For a more detailed discussion, please see Weiss 2001

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He reassured me as well, explaining everything clearly and respectfully without any judgement