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Mechanistically, SFN achieved S phase arrest through the modulation of the p53-dependent p21-CDK2 axis, effectively inhibiting CDK2 expression while upregulating p53 and p21 levels

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PLoS One 3, e3791.10.1371/journal.pone.0003791 118 TahaH.SkrzypekK.GuevaraI.NigischA.MustafaS.Grochot-PrzeczekA.FerdekP.WasH.KotlinowskiJ.KozakowskaM.BalcerczykA.MuchovaL.VitekL.WeigelG.DulakJ.JozkowiczA