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Although TCR recognition is supposed to target the specific peptide-MHC complex, the possibility of off-target effects due to the cross-reactivity against epitopes in unintended targets still represents a severe complication for cancer patients ( 7.9 CSK in activation of human B cell and B-cell receptor (BCR) therapeutics Similar to TCR signaling, B cell antigen receptor (BCR) signaling is also regulated by SFKs

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Immunoprecipitation Assays Anti-C2Cat (5 L) was incubated with 50 L of packed volume of protein G (Invitrogen ) for 2 h at 4 C

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