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For example, in hereditary leiomyomatosis and renal cell cancer (HLRCC), a high level of fumarate caused by genetic mutation of fumarate hydratase induces the succination of Kelch-like ECH-associated protein 1 (KEAP1) accompanied by the consumption of a fumarate molecule 134,135

Die Schneider-Helmert-Studie 1985 dokumentierte signifikante Verbesserung der Schlafqualitt und reduzierte Schlaflatenz bei Patienten mit chronischer Insomnie

This attack results in the reduction of the protein substrate and the formation of a mixed disulfide bond between the N-terminal cysteine residue of the Grx-S-SG

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doi:10.1097/00005392-199709000-00005 Ehren I, Lundberg JO, Adolfsson J, Wiklund NP