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Amyotrophic lateral sclerosis (ALS) is one of the most common types of progressive and fatal neurological disorders which results in loss of motor neurons mostly in the spinal cord and also to some extent in the motor cortex and brain stem

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This system is disrupted through pink-1 loss-of-function wherein mitochondrial fragmentation occurs due to reduced capacity for stress-induced autophagy and potentially leads to protein damage and, in neuronal compartments, neurodegeneration

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