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10.3390/pharmaceutics14010160 98 PennazioF.BrassoC.VillariV.RoccaP

Unlike nuclear DNA, mtDNA lacks protective histones and has limited DNA repair capacity, rendering it particularly vulnerable to genotoxic stress, such as from reactive oxygen species (ROS) generated during oxidative phosphorylation (OXPHOS) (31)

This effect was accompanied by downregulation of RAF and RAS mRNA and protein expression, suggesting a potential combinatorial therapeutic strategy (75)

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Scutellarein alleviates chronic obstructive pulmonary disease through inhibition of ferroptosis by chelating iron and interacting with arachidonate 15-lipoxygenase