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Disulphide bond integrity: Uniquely important for this compound, the disulphide bond between Cys-7 and Cys-15 must be correctly formed

This work was supported by the Japan Society for the Promotion of Science (JSPS) Grant-in-Aid for Young Scientists (B) Grant Number JP15K19036 (SH), JSPS Grant-in-Aid for Young Scientists Grant Number JP19K16271 (SH), Japan Science and Technology Agency (JST) ACT-X Grant Number JPMJAX201A (SH), RIKEN FY2018 Incentive Research Projects (SH), and Naito Grant for female scientists after maternity leave (SH)

These studies generally demonstrate favorable safety profiles, although their therapeutic efficacy is often limited by poor aqueous solubility, rapid metabolism, and low systemic bioavailability

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[DOI] [PMC free article] [PubMed] [Google Scholar] 19.Valdivia A., Ly J., Gonzalez L., Hussain P., Saing T., Islamoglu H., Pearce D., Ochoa C., Venketaraman V