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442444 Flavonoids are synthesized by a type III PKS with a starter unit derived from aromatic amino acid catabolism, such as p -coumaric acid ( 227 ), caffeic acid ( 228 ), or ferulic acid ( 229 ), followed by several rounds of polyketide chain extension using malonyl-CoA as an extender unit (Figure 50)

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[17] The ratio of reduced glutathione to oxidized glutathione within cells is a measure of cellular oxidative stress [18] [11] where increased GSSG-to-GSH ratio is indicative of greater oxidative stress

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Prediatr., 551-556, 1981