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A number of research studies have investigated the neuroprotective effects and therapeutic potential of ergothioneine275, 276, 277, 278, 279

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These were attributed to the inhibition of inflammatory mediator release, reduction of capillary permeability, and reduction of red blood cell aggregation

Scorticati C, Prestifilippo JP, Eizayaga FX, et al

In Noonans syndrome genetic defects in the PTPN11 gene may affect this pathway and has been implicated in poor growth and poor response to GH therapy, although reports are conflicting (99, 100)