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At the molecular level, insulin signaling in hepatocytes primarily involves the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) pathway, which promotes glucose uptake, glycogen synthesis, and lipid regulation

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Simultaneously, there are also changes in fat composition in these patients, as SCI impairs the adipose tissue distribution pattern, affecting both white adipose tissue (WAT) and brown adipose tissue (BAT) [175]

As this process repeats, the area may begin to look darker or more uneven in tone

In addition, eprosartan has proven effective in an ischemia/reperfusion-induced kidney injury model by enhancing mitochondrial function by activating the Sirtuin 1/PGC1/Sirtuin 3 pathway