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Simultaneously, astrocytes respond to chronic hypoxic stress by undergoing reactive astrogliosis, characterized by elevated HIF-1 and HIF-2 signalling and secretion of VEGF-A, which disrupts tight-junction proteins such as occludin and claudin-5
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Valverde et al., 2019
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Allosteric regulation of phosphofructokinase-1 is also substantiated by activation by ADP (weakly) and AMP (strongly, which is generated by adenylate kinase from two ADPs to regenerate ATP) and by inhibition by citrate
Nat Rev Neurol 16:636644
