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The use of rhGH after transplantation leads to catch-up growth associated with increase in IGF-1 levels [26]
In a study on rats, DSIP demonstrated an analgesic effect, increasing the threshold for pain response (Gyermek et al., 1981)
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Mutation of this enzyme leads to fumarate accumulation not only in skin cancer and uterine leiomyomas but also in breast, bladder, and Leydig cell tumors 130
100 mg/day for children 1-3 years
