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Atherosclerosis 188, 455461 (2006)

Additionally, premature ovarian failure or androgen deprivation (from cancer therapies) can produce hormonal changes associated with fatigue for example, abrupt menopause in women or testosterone deficiency in men may precipitate lethargy and muscle weakness

45 Metabolism beyond ATP production Metabolic intermediates may act as regulators of many pathways not directly related to ATP production

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To further test this hypothesis, we measured the glycolysis rate in mice that had been treated with clenbuterol