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1996;64(3 Suppl):524S532S
[DOI] [PubMed] [Google Scholar] 117.Lv Q.Q., You C., Zou X.B., Deng H.Z
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In the absence of MTAP, the substrate methyl thionyl adenosine (MTA) accumulates and acts as a selective inhibitor of PRMT5 to inhibit PRMT5 methylation activity, 237 whereas MAT2A can produce the PRMT5 substrate SAM, 238 allowing PRMT5 to exert its oncogenic effect
2015 doi: 10.1001/jamapsychiatry.2014.2502