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Investigating the Role of IGF-1 and Insulin Receptor Mutations in the Pathogenesis of Keratosis Pilaris: A Theoretical Framework for Symptomatology and Underlying Mechanisms Author: Devin Beaubien Last Updated: 4/4/2025 Introduction The skin condition Keratosis Pilaris(KP) is primarily the result of a skin barrier issu

By contrast, the inhibition of the de novo synthesis of GSH, by deleting either the catalytic (Gclc) or the modifier (Gclm) subunit of glutamatecysteine ligase (Gcl), dampens intracellular GSH, increases ROS, and impact T cell differentiation