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Since Pdcd4 functions as a protein translation inhibitor, 13 it is possible that Pdcd4 knockdown promotes p70S6K1 translation and thereby increases the p70S6K1 protein level

doi: 10.3389/fnut.2025.1746176 Received 14 November 2025 Revised 03 December 2025 Accepted 17 December 2025 Published 12 January 2026 Volume 12 - 2025 Edited by Iris Joye, University of Guelph, Canada Reviewed by Soubhagya Tripathy, Indian Institute of Technology Kharagpur, India Prakasha R., Anand Agricultural University, India Updates Copyright 2026 Hao, Tan, Liu and Xin

Placental Origins of Preeclampsia: Potential Therapeutic Targets

[DOI] [PubMed] [Google Scholar] 62.Schmidt EE

ACSL4 is generally upregulated in OA cartilage tissue, and its continuous activation expands the pool of oxidizable lipid substrates, thereby significantly increasing the tendency for ferroptosis (Guan et al., 2025
Therefore, designing TME-responsive and TME-modulating nano-DDSs may be of great interests for new generations of cancer combination therapies
