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Vidal A, et al

H.Carvajal-SandovalG.et al (2008)

The complete removal of intronic regions flanking the GAA repeats showed the most significant restoration of FXN expression, compared to elimination of only the GAA tract, offering a potential therapeutic strategy for FRDA

Notably, mechanisms may include targeting of GPX4 expression and xCT, the Nrf2/GPX4 signaling pathway, the UCKL1/Nrf2/SLC7A11 signaling pathway, miR-19a, miR-545, and lncRNA LINC00239

High-dose vitamin C and zinc at home during cold and flu season, pre-travel, or when you would rather not sit in a waiting room

B.Constantin-TeodosiuD.LaithwaiteD.SimpsonE
