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doi: 10.1101/cshperspect.a033217

Wilson's disease The protein, ATP7B, is responsible for the excretion of hepatic copper into the biliary tract, and its impairment in Wilson's disease results in an increased concentration of 'free' copper (i.e., not bound to the copper-carrying protein, ceruloplasmin) in blood, an increased excretion of copper in the urine (hypercupriuria), the deposition of copper in part of the cornea (forming Kayser-Fleischer rings), and the accumulation of copper in the liver and brain (106)

Deboever N, Ostrin E, Antonoff MB

The role of H 2 O 2 in thyroid physiology Hydrogen peroxide (H 2 O 2 ) is a form of ROS

Antioxidants prevent oxidative DNA damage and cellular transformation elicited by the over-expression of c-MYC

Several treatment options for T2D are currently available, thereby requiring that decision-makers understand the relative clinical benefits of each treatment to provide the best recommendations within budgetary constraints