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PIK3CA mutations in plasma circulating tumor DNA predict survival and treatment outcomes in patients with advanced cancers

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The primary iteration, exemplified by hereditary hemochromatosis and juvenile haemochromatosis, predominantly arises from genetic perturbations, which attenuate hepcidin levels and enhance bodily iron absorption, instigating excessive iron deposition within internal organs [767, 770773]

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83 Also, METTL4 was found to catalyze mt-DNA m6A in human cell line

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