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Description
Rheological behavior The rheological properties of PC200, PC202 and PC204 were measured using a Physica MCR301 rheometer (Anton Paar, Austria), operated with parallel plates (diameter 25 mm)
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doi: 10.1007/s12282-019-01012-y 107

ALD is the most common peroxisomal inborn error of metabolism, with a minimum estimated incidence of 1:42,000 for hemizygotes and 1:16,800 for hemizygotes and heterozygotes, though the incidence is likely to increase with improved newborn screening
Furthermore, FAO capacity, measured by palmitate-stimulated OCR and expression of FAO enzymes (CPT1a, ACADL), is significantly impaired, preventing the metabolic reprogramming required for M2 activation (Liu et al., 2023)

Summary: Adults with B12 deficiency and nerve pain typically require 1 mg hydroxocobalamin injections intramuscularly on alternate days until symptoms improve, followed by maintenance injections every two months
