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In addition, a wide range of studies have shown that NNMT is elevated in various cancers, including squamous cell carcinoma (SCC) (27), colorectal cancer (12), renal cell carcinoma (28), bladder cancer (29), ovarian cancer (30), cutaneous malignant melanoma (CMM) (31), gastric cancer (32), pancreatic cancer (33, 34), and glioblastoma (GBM) (7)