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Furthermore, small molecules like ABX464 offer a distinct advantage: rather than flooding the body with synthetic RNA, they enhance the biogenesis of specific endogenous miRNAs (miR-124) via stabilizing RNA-protein complexes, a mechanism that has demonstrated a favorable safety profile in Phase 3 trials [95, 96]

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doi: 10.1007/s00244-008-9194-6, PMID: [DOI] [PubMed] [Google Scholar] 27.Bonato M, Corr F, Bellio M, Guidolin L, Tallandini L, Irato P, et al

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