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His-tagged proteins (green) bind to nickel agarose beads

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Moreover the dose modification factor (DMF) for the PtII agents were lower than those for PtIV agents in the three cell lines

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Additionally, p53 regulates the biogenesis of iron-sulfur clusters and the copper chelator glutathione, which are two critical components of the cuproptotic pathway, suggesting that this tumor suppressor might play a role in cuproptosis
