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doi: 10.1371/journal.pone.0015360

This accelerated energy generation is crucial for supporting the uncontrolled proliferation of tumor cells, especially under the high metabolic demands associated with KRAS mutations

If excess FAs are deposited in ectopic tissues, this could lead to lipotoxic effects of FAs

Best Practices: Take NAC on an empty stomach to enhance absorption

Therefore, TCA cycle influenced the rate of NADP + reduction mediated by IDH2, and acetyl-CoA (Ac-CoA) from FAO could satisfy the demands of TCA pathway

98,400 Although these drugs have been widely used, ongoing research focuses on optimizing dose, dosage form, routes of administration, and combination therapies to minimize adverse effects and improve patient compliance as much as possible