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Interestingly, mediation analysis showed that TMAOs adverse effect on kidney function strengthened at more severe stages of cardiometabolic disease, implying TMAO synergy with existing pathology (thereby providing 2-hit model)

Then the quercetin radical intermediate is stabilized through delocalization of electrons across the flavonoid structure, preventing further propagation of oxidative damage

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Le Roux, C

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[DOI] [PMC free article] [PubMed] [Google Scholar] 26.Hassan A, Din AU, Zhu Y, Zhang K, Li T, Wang Y, Xu S, Lei H, Yu X
