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This phenomenon, known as the Warburg effect, is a hallmark of cancer metabolism [23]

The primary mechanism underlying ferroptosis is the accumulation of iron and lipid peroxidation, leading to a perturbation of oxidative homeostasis within the cellular microenvironment [220]

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Aikawa, M.J

10 , e1087629 (2015) Johnson, C.S., Kolevski, B., Smyth, D.R.: TRANSPARENT TESTA GLABRA2, a trichome and seed coat development gene of Arabidopsis , encodes a WRKY transcription factor

Overall, safety hinges on dosing to phenotype, respecting phase-of-disease timing and coordinating with therapies that intentionally leverage oxidative mechanisms (2022