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Description
Bioengineering techniques can create characteristics that may be very rewarding, yet, they can also be detrimental, if not properly handled

The relationship between MOTS-c and metformin deserves careful attention

However, anti-HER2 CAR T cells that further lower the HER2-targeting threshold caused fatal respiratory failure because of on-target, off-tumour toxicity to the low HER2-expressing cells in the lungs 290

PMID: 34752566

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Endocr Relat Cancer (2013) 20:495505
