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While cyanocobalamin can still raise blood levels, it may not act as quickly or effectively in neurological tissue

B12 is unique among vitamins because it requires a complex absorption process

Mateuszuk L, Jasztal A, Maslak E, Gasior-Glogowska M, Baranska M, Sitek B, Kostogrys R, Zakrzewska A, Kij A, Walczak M, Chlopicki S (2016) Antiatherosclerotic effects of 1-methylnicotinamide in apolipoprotein E/low-density lipoprotein receptor-deficient mice: a comparison with nicotinic acid

Studied exclusively in preclinical animal models in the context of gut, joint, connective tissue, and inflammatory processes.* 1-8