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Dysbiosis of the intestinal flora and alterations in its metabolites are closely associated with the progression of COPD, while COPD also affects the intestinal flora and its metabolites (66)

Key metabolomics techniques include mass spectrometry (MS), nuclear magnetic resonance (NMR), liquid chromatography (LC), and gas chromatography (GC)

Often the symptoms progress only very gradually over time

[5] There is no reliable way to predict which form of the disease an affected individual will develop, with multiple phenotypes being demonstrated within families

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doi: 10.1016/j.molmed.2023.05.013 33 PanWZhangJZhangLZhangYSongYHanLet al