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Borneol downregulated the expression of PGP and increased the accumulation of rhodamine 123, an efflux pump ligand, in brain endothelial cells and the transport of digoxin and verapamil across the BBB model [110]

Glutathione deficiency is usually characterized by a reduction in the body's ability to detox, inability to repair DNA, increased cell mutations, increased oxidative stress, and reduced oxygen and nutrients supply to cells

For instance, berberine inhibits endothelial ferroptosis and AS by suppressing ACSL4 expression (Hong et al., 2024)

Signal transduction, redox homeostasis, cell-to-cell contact and secreted factors present in the TME can prompt differentiated tumor cells to reacquire stem cell-like characteristics

Classic monoamine hypothesis is an early milestone in the field of depression

P.Biosynthesis and toxicological effects of patulin.2010613 EOF31 EOF 133