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These results indicate that more must be done for the field to understand how more specific metabolic mutants, such as uhpT or metabolite-specific PTS mutants, regulate their virulence gene expression through PrfA

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Zhenwu decoction, which functions to warm yang and induce diuresis, can reduce the expression level of TGF-1, upregulate the expression level of PPAR, increase energy metabolism, alleviate oxidative stress, and regulate fibrotic cytokines, thereby exerting renoprotective effects and improving RF [158]