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4.1.1 Enzymatic systems Superoxide dismutases are the first line of defense, dismutating superoxide (O 2 ) into H 2 O 2 and O 2

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Plant Physiol 120:10151024 Mittova V, Theodoulou FL, Kiddle G, Gomez L, Volokita M, Tal M, Foyer CH, Guy M (2003) Coordinate induction of glutathione biosynthesis and glutathione-metabolizing enzymes is correlated with salt tolerance in tomato

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In the BRONCUS 45 study, there was no difference in the SGRQ scores between the treatment and control groups after 1-year treatment, and there was no improvement in the quality of life with NAC therapy in the second year

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39 Based on a physiologically-based pharmacokinetic [PBPK] model in healthy adults, ~88% of CP1 total clearance was attributed to hepatic elimination with the remaining clearance ascribed to renal elimination

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Financially, patients need to consider not only the cost of the medication itself but also expenses related to ongoing medical monitoring, potential additional therapies, or management of side effects

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