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This result can be improved by using an aggressive laser along with a biostimulatory filler (like hyperdilute sculptra or radiesse), which will restore and repair the collagen in this area, as well as erase sun damage and deep wrinkles

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Characterization- and formulation-associated issues include the correlation of in vitro model with in vivo studies, the usage of a high amount of surfactant, the precipitation of drug in vivo, the oxidation potential of lipid components, the difficulty of low encapsulation, etc

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