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Interestingly, when compared to the GN-treated group, the carrier NPs-CS and -spanlastics did not significantly modify renal parameters, indicating that they did not worsen damage processes or impair baseline renal function

Conversely, acute or chronic inflammation and stress have been found to increase the throughput of the kynurenine pathway, leading to an increase in tryptophans conversion to kynurenine [32,55]