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summarized clinical and experimental evidence showing that circulating irisin increases with exercise, promotes osteoblastic differentiation, and is associated with lower fracture risk (39)

J Am Med Dir Assoc 2021;22(7):13331337

M., Cheon, S

[] Conversely, developing countries may underreport cases owing to restricted healthcare access, diminished PSA testing, and reduced life expectancy (the risk of PCa increases with age)

To the best of our knowledge, no relevant articles currently summarize and explain these contradictory observations