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For a 500mcg dose: 500 / 5,000 x 100 = 10 units (0.1mL)

Affected individuals with more severe defects presenting early in the neonatal period, infancy, or early childhood have a poorer prognosis, especially if diagnosed in a symptomatic child rather than through newborn screening

however, trim-and-fill imputed no missing studies, and the pooled estimate was unchanged (SMD 1.201, 95% CI 2.115 to 0.287)

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Be Extra Cautious During Pregnancy: During pregnancy, when hormone levels are high, be exceptionally vigilant with sun protection to prevent the onset of chloasma, or "the mask of pregnancy." Be Mindful of Heat and Light Sources Emerging research shows that factors beyond UV rays can influence pigmentation, particularly in melasma