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According to the US Food and Drug Administration, Betnesol is a category C drug, which means animal studies have shown adverse effects on the unborn, and there are no well-controlled studies in humans (5)

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Utilisation en cas d'insuffisance rnale grave Chez les insuffisants rnaux svres, une augmentation des doses (ou une rduction de l'intervalle d'administration) peut ventuellement tre envisage car la rponse thrapeutique la vitamine B12 chez ces patients peut parfois tre diminue

Mirrors the mouse study design adapted for subcutaneous administration