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Because the field is composed predominantly of observational and single-arm trials, the risk of publication bias toward positive associations is acknowledged

Liver Int 2022;42:72941

In laboratory studies, inhibiting NNMT has been investigated for effects on cellular NAD+ levels and adipocyte (fat-cell) metabolism

doi: 10.1146/annurev.immunol.24.021605.090737 167 AmarnathSMangusCWWangJCWeiFHeAKapoorVet al

GHRH analogs like sermorelin or CJC-1295 with Ipamorelin require more careful consideration but are not strictly contraindicated

Similarly, 2,2-bipyridine, a fast-acting iron chelator that acts similarly to DFO, protects LAMP-2 knockdown cells from tributyl phosphate (THP)-induced cell death in human RPE-19 cells and in primary fetal retinal pigment epithelium (52)