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Additionally, -elemene promotes the maturation of miR-127-3p by inhibiting CBX8 activity, which subsequently inactivates the AKT/mTOR/P70S6K signalling cascade via MAPK4, leading to autophagy induction in NSCLC cells [184]

J Heart Lung Transplant 26(11):11771181 Sam F et al (2005) Increased reactive oxygen species production and functional alterations in antioxidant enzymes in human failing myocardium

Circulation 149(8):e347e913

4a) G6PD is commonly overexpressed in many myeloid and lymphoid malignancies leading to improved proliferation, but this effect can be abrogated by pharmacologic inhibition of G6PD 87

Cells 9:1489

However, the effect of these drugs in neurological diseases requires further testing in vivo