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Approximately 30% of patients experienced gastrointestinal adverse events, which resolved spontaneously or with a reduction in the NAC dose [42]

CYP2E1 under GSH depletion activates ERK MAPK pathway in HepG2 cells [41]

Clinical studies have shown that taking 3-5 mg of melatonin orally at night can significantly reduce the Melasma Area Severity Index (MASI) score

doi: 10.1177/039463200401700105 79 MassaGVanderschueren-LodeweyckxMBouillonR

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10.1016/j.ecoenv.2021.113096 54 Dias da SilvaD.SilvaE.CarmoH