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Mutant IDH results in deployed lipid synthesis Increased synthesis of KG through mitochondria means decreased levels of KG substrates like citrate
It is responsible for several serious clinical syndromes in both humans and animals with listeriosis being typified by high mortality rates (20-30% in humans) despite antibiotic intervention ( L
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6c), a result implying that SF3A1 promotes translation, beyond being important in splicing
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Emerging mechanisms of obesity-associated immune dysfunction
