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In addition to the secretion of immunosuppressive factors, MDSCs engage in direct interactions with T cells, preventing their activation and proliferation [18]

For influenza virus, nAbs to the HA stem region require Fc-dependent effector functions to mediate protection whereas nAbs to the HA head region do not 173,174

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Another comprehensive study from Genentechs National Cooperative Growth Study examined 40,000 children undergoing GH therapy with prolonged follow-ups and compared them to age-matched general public without known leukemia risk factors and showed a comparable incidence of leukemia for GH recipients (297, 298)