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, no further decline or projected decline), and disease-modifying impact on the underlying etiology (not just late-stage growth of scar, once tissue is lost) represents clinically meaningful benefits, the authors concluded in their paper

Cloudiness usually indicates bacterial contamination, which is another problem entirely, but a lack of cloudiness does not guarantee the product is still active

Even if cytokines were meaningful peripheral biomarkers: Blood cannot be compared to cerebrospinal fluid Even within blood sampling: Venous and arterial blood samples cannot be compared Even if blood sampling methods were equal: Plasma, serum, and PBMC sample matrices cannot be compared Even if ME/CFS researchers use a consistent sample matrix: Bioassay, ELISA, and multiplex assay results cannot be compared, even across kits of the same assay type Even if ME/CFS researchers standardize their methods: The same exact lab, personnel, and protocol will likely get different results from the same manufacturer's kit The relevant details of methods used in previous studies of cytokines in ME/CFS are listed in Table A1

To this end, we performed a post hoc analysis on a subset of the study population that is characterized by increased oxidative stress, as determined by the values above the median for MDA, while showing low levels of baseline glutathione levels, as characterized by values below the median