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We have recently shown that fibre cross-section is reduced at baseline with up to 19% reduction amongst several white matter tracts in cognitively intact patients with PD who progress to poor outcomes within 3-year follow-up 141 (Fig

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In light of these emerging findings, this review systematically evaluates current evidence on gut microbiotas mechanistic involvement in PCOS, with particular attention to microbial metabolites and their systemic effects, while critically assessing the translational potential of microbiome-targeted interventions for this complex endocrine disorder

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