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Experimental sleep deprivation leads to endothelial dysfunction, an early marker of atherosclerosis, as indexed by impaired endothelial-dependent vasodilation or increased levels of endothelial adhesion molecules 191

A common protocol involves using a bioregulator for 10 to 20 days, then taking a break before repeating

CytoNCA (Tang et al., 2015): A plug-in Cytoscape, which is used for centralized analysis and evaluation of protein interaction network

The names of the repository/repositories and accession number(s) can be found below: Ethics statement The animal study was reviewed and approved by the Institutional Animal Care and Use Committee of Guangxi Medical University