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What we should focus on is reducing HARM

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Of note, in vivo varencline also has antidepressant-like effects in the forced swim test, and is able to augment sertraline's antidepressant effect via its action on the 42 receptor

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As far as interaction with psychotropic drugs in concerned, polycyclic aromatic hydrocarbons within tobacco smoke play a more decisive role by inducing CYP1A2 (Table 1)