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The propensity score was estimated using logistic regression as the probability of starting a GLP1 receptor agonist versus a DPP4 inhibitor conditional on a number of variables, including sociodemographic characteristics, medical history, other diabetes treatment, and markers of healthcare use, at cohort entry and stratified by country (etable 3)

Several studies reported that inappropriate ANGII/AT1R activation occurs because of different mechanisms, particularly in patients with T2DM

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The chart below shows the expected mortality impact of these scenarios at the population level

The escalation proceeds through these doses with the 25mg tablet as the target maintenance dose