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What this means for your strategy If you are a market access team planning a European GLP-1 launch whether for oral semaglutide, tirzepatide subcutaneous, survodutide, orforglipron, or any of the seventeen GLP-1-based assets in Phase 3 France just became the reference case

Furthermore, there remains debate as to whether the liver can directly respond to GLP-1 or if the increases in liver glycogen metabolism are due to GLP-1 augmentation of pancreatic beta-cell insulin secretion

Considering the prolonged half-life of most GLP-1 agonists currently prescribed, it is unfeasible to withhold these agents for weeks prior to surgery to achieve normalisation of gastric function with unknown impact on aspiration rates, appreciating the detrimental effects of poorer glycaemic control on withholding these agents and associated higher risk of peri/postoperative complications (major cardiovascular events, poor wound healing, increased wound infection etc.)

Let's Talk GLP-1 GLP-1 is a hormone that helps you feel full and satisfied

Most people lose 1-2 pounds per week on average